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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '541f1ad3ae2a715251e46eb64da125f9ff62767d40efffee8fe275f0c3243b91' 
  AND token = 'EGIyXQx8NeqCZad1R94iXwViHaosynHDZq6zAvG4KGo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}