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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45617c11d3e1540b2787fa45ea0fcf4f090c87b65e11090563d723680fe0ad41' 
  AND token = 'JQ0EPpGwKMgch+9IN5w6PGemg6UIKuuEXFlZUISidvs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}