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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b665137ea578a62273b5c6a0cdf9c7125cca08bf7b422d592fa3cf5295c1bd3' 
  AND token = 'NqSFw31dEFl0MhH5xv84nQSxfFWZ/ggZ7ZFZjONfWvI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}