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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '54162a8226f4a21036e104a2c6f3838e2917371cca02d63155e047457f30d223' 
  AND token = 'PEs4G7qoo56BlS2jlG/nX69Q1uGfGiwYi7TqhnfN7HI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}