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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '537c05f5684fe32fda3b5c4fe07b987baa43649e6d2942d336b9743b6cb3e0f4' 
  AND token = 'uFEotApLZEwdKtn37anBnaAajeEYpOHYrVgOO3bty3A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}