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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81baaa8c40b917d515788b4ea6bef6a1a78cb32f13fbd41e8fc6992aaa404870' 
  AND token = '5AOO78/NKbzba0q7vH777yjt+jsBBBGAXQa7CvADswk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}