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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a294d272a7244df0b912fed7c451060fb4c95b8279eed6f94078af36356ae528' 
  AND token = 'YXpMZvQt9llMR+uoEwRE4MCLsFlCRFiqIt5RLiB29FM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}