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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b46b823d24b8d9126314e04a7e5e077afac5b5a54772c880da19378c8691e3ec' 
  AND token = '0q1VUmAJKEvgJhULaCBvs6NicCnvBh6WIEPNldkfio4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}