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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49f334f8667ca277147160f86afe216fd8f8eecec8e88e728894755b9cd7c24f' 
  AND token = 'BlODsP3SeJQ1GKgU1sQAs4kUgCBRvY1ae4nchB60zCs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}