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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65e327942dfcb1f4bd6e1f9532593b782bdb35631d2740411c8c455b49cb9c25' 
  AND token = 'Gksy9143E+OmO/n44hiuXuxMEv+LRq2VVKZ3Gamao0Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}