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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25f36a16371a400f1d304eef251ddd1ed87bcfda6e15b8f6b43e96439995caf8' 
  AND token = 'LaNPeMYxIm8nKKN7swBOm0VWLs4SF1FBN/EQpFWYnjQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}