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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18912db07f09f3fbad30df3a88a1a04ad35edc2cb10cd58dbb4ff36e9a297bc9' 
  AND token = 'MPyEaeRy3YUIix5oZgtGQ01nU9Bmmt/Ik8chN94VFB0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}