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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '108cef2ec425ac036c03a10a4b7ea010d2e56c918fb747cbb581bf386d09ae78' 
  AND token = 'ej5WDgTACzp+Pj9ezxCPcp3QnDDhTuuJZRpU9mvBPAo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}