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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1d38d806275f3aa094371e17012d56788ee85d4eae7ac0e1a72a2c25aa39dc80' 
  AND token = '+xX33UNft1lIAnAn7HoApafYBsyH2xEgBI1EzY6O31c=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}