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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5d0420b3390c44b7e36d8062559c630122a09e91494a0f1c9d8cfa9e4aa49fde' 
  AND token = 'cH8g3ydUFUpdCmB/jY1UB+eee4ye22uIBX0MYQ/jqW0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}