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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '455addcfa6e6ca9cbcce44f416ab658eef5c8a57e7620de03643efeb6f889c34' 
  AND token = 'hZTt0hWQ1lh9E+DndeUUC5BE3hQQmPZuAFfMRkv9tRs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}