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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '144b1b3f27334a4a196c2dcabf88a3bdb221a3e9ec065b64ce99351c054a44de' 
  AND token = 'qA+SAuqf0BUJjmc+PY9dPlSnRyG8NRzosrvifxVLOeI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}