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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '251b10d37bc783252a5ddc4d472c3903e73e6c479b3de1644badd256e2d44637' 
  AND token = '6RYtNVQVFP1rDTZSoCqN4TNUnxxC9AJDAySJptSTr14=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}