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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd54653add04b1393e2ac548e5c6adb75724a4d246f95b84b3ede7c9e74a0f416' 
  AND token = 'g8//GgSTHN9e5PzwbPa8u9v2qEAYKDcB4iTQbJd2TIw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}