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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43d1d8d62b6600ddcdfa80a843cf778b4d02c85d8595e2cd256fbbbd02755464' 
  AND token = 'fQdTbvTB40bgVi6+tcwd3ytjlfEn9byV8YPJtjtCXb0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}