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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2da78b61b8887cfb4b1af5680612ba2d589cf8b4ad1bdbb9b69973d6050c837f' 
  AND token = 'Nklb3IImvNVxPF5/7RauWRVXWyF3eqafTHDXFpMeomg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}