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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4268c16b52d6820bbf7d182f2711120a8948d0ca05b80bf3f68378dd0f9be074' 
  AND token = 'MJR557AqSI3yeNtSHMxmh1wsKjm9z2eiUeCGv2pk00Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}