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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8fc48ed4c582d2482d058ff00288882756e7652cbc6de3afc8076d69d73a4f9f' 
  AND token = 'lmxg3dPv7+NaoWECxLWm8xuctHKiknn3Km+Zp96CNqI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}