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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25b47aef3209fff89e51e5995e8978ddb75fecc9c552fd781c1b2fd812360071' 
  AND token = 'w5UEsbuIMMTGIHbSeeIy2rEzCWvs/6eGsXZZBM3TYdM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}