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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4665451f3729cdaefa6e99311513e1456d75965496cf3dcf081ea1b618033e20' 
  AND token = 'l+KT/VWnWyDj6bSPe+Sanb1j5aC14ENDfNf38a1jLUI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}