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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '250a800828226269ed41e5ae4b7157ad56e49712e751ba27252adf5adb087eb1' 
  AND token = 'C7iuROL3sj5Vz6//l/NpBUx9tkT/3t5Reob6p+8mLnQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}