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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '850f7498854dce71e7327ca76154a8190f78efe727bd36306796b331d4ba5af4' 
  AND token = 'kMsW38Je0d+YjcLN1pPdHmSp67hAiUq95Dc6SCs42YQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}