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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22b5efa0e9256f3f799532fba18fd1b8988d189af3c781f678b4a588b2950023' 
  AND token = 'F0k4c9AUEv2NgM089Xw0giZ13NXoFNQXiqmTcqCOLys=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}