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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b0b60773400935346153d3a1fd0481d00f546cf04f226013f431f468e2b45006' 
  AND token = 'calw9RVs3n40XNLdRfYBE5WuDuzA7XioibGufwn6lYs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}