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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e2d7620006ffff441253702854806af278c4a8ccba4abf070408b269cc2be53' 
  AND token = 'nEL49Q6FcNnxTeDbXZLD260/XSr46RwsZWGExs9Te8g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}