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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21ca1bcc8e4013f89092f25dbd4e36d5c65616dc46c70c61f0324286f5898386' 
  AND token = 'V7wsisfQ7TWEhIB0goTvIVVbJTaiORHc5OqkqThlWY0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}