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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cf64864b69df159231b216d630c64c60b15201e51bcd218b57c7183ff04bf654' 
  AND token = 'fGwUUiDHq/4+wkyR0Q9P2kqpZTboV6jHAm0f1qHs3Qc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}