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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f37c1bd10e8488cbcb998d87fed711bbcdaaa793003585a99204465d31bb022f' 
  AND token = 'GPvGuVi2moz1B8DKwFrOM7iCq0MBYb6a/2qIIcfN2oQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}