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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e51b16d8510b566b2bce0e762bc2042f91f2653a02e4df202c219aec6d7d1e72' 
  AND token = 'nTewr1sAGppv/QDBXcnzfumP2m7hSdLQVT4x/0UFQVE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}