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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6457f6767deb83cfd48a03290e16bc372665f1d21d63f5846941d64da1a5d818' 
  AND token = '1VCx/1RIOlcFscsaxsQF1TVEqUaRGS8jd3Qme9nwlPY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}