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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a3c57fe3115518d1f25f566f5ebd33552c537bcd5658513ad0452987f22c6091' 
  AND token = 'xPXRT+0gO1xWB6y/X5Q253sAYjw3PcgxykVzorVhMOY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}