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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c28b681f0ae1ceed349d5691f8d3c49e3e1370ae5d6fc3da07f4033f106d31ef' 
  AND token = 'wpD/eJNAQXNNuSjgzHmk/S0dXsXKnBurj1yquAP0o8s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}