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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '639458d271fd2699dab1497a8eb69377fd754e38d0a5f5f24b3e672ad6556521' 
  AND token = 'PpUfPN7Olh+bsosw40DbaK9PN0pp3oSk0FTWm4snOcM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}