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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7e757ed55d9618d019dea10128db9d85c10e124c506e825221a8b3f7fd5fe44b' 
  AND token = 'nMk/2ipL4rkB40yYJYOvnrSFSWA3TcmSnjy0/2C22wQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}