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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7515b986acfa9dd0457cc55e2405e01bd2a2d80c4aaf24da97b4e8b3821f8181' 
  AND token = 'JwEOqJ7dHdKrS7Xr/byStL2uCFr5IRHq990gtjNE7K8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}