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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12e99310d0124fc0e1cb989c0296fe36a5d886468ff1dd403f7c8ed3b19a40c5' 
  AND token = 'Xb+7e3/JjuYMLzQgTae5bicw6d0N9TjLOhArlx4zq0Q=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}