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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd5a1f26b6413d50aad446a27f00518c4387641d1d757802e9465c046e78561e3' 
  AND token = 'OChsDY7j4tf15Ja6UzhqGyYxJmKV4qJCzs28iLJJwOM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}