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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '50a10b68d8e7b2a8b62b3009b5b811b2e6e5e778523e8e04ff6a3e34716794ef' 
  AND token = 'XmaNZaIRFKNdQdTdJrjLz7nOMsdNpgPZQX5tcyKZmb8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}