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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '050b5949cc53b004e9c8b5ecb3b917e9aeb9f922649b2a91f250f0e2aec635be' 
  AND token = 'u+FLCQ1a7gPoTXT6IbjsH1opQ9agyhAUiAWYnYs70kc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}