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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45224de27ba9183585bf72e58ee0d06029270a033719598421ec1a0af90d3121' 
  AND token = 'YnSQ+jkDFNwR5phU7IzPlyl/sAbI9Pzm7oYfS5fgOho=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}