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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80b3b8f38df38427a146d56435e3629a88d24c8f7db5ce30628ee95b905f1006' 
  AND token = 'PGL6qvnG0k0TmzzZlSXzcxpOibXZeNALTyUwyR5ue28=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}