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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '21adb7c04be48d6682648924d9db51770d1d1277f372b89cffd599413fc22d1b' 
  AND token = 'uzfE+iAmEUePmh8ZPad8Jkzu2gAngYnu4aAKtBRPC1Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}