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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22d46ae538e657cf9c4668c9b189dad580f527801195a72b481ab6e238184507' 
  AND token = 'MjWGxc/rlpRE7u53nrEj8h4cGx/9prKtsTFn4NXLyxY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}