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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2c9f227cbde63a2529e014a0f29a6f65dc7347d3b84ce80837e715f9d3043542' 
  AND token = 'OtVN6nwd8olH3OyJh5Vt6rTmxb687ngY7mG9LMzrKac=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}