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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '81b0b0b5ad566cd047163b499fb50256fff11f1cd980af32e06d4bffa2c605a4' 
  AND token = 'NKPb7PJPx3i/D343jUw627IynhsauMzrE+w1wLXOg5g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}